Selected publications

1. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.

Gyimesi M, Horváth ÁI, Túrós D, Suthar SK, Pénzes M, Kurdi C, Canon L, Kikuti C, Ruppel KM, Trivedi DV, Spudich JA, Lőrincz I, Rauscher AÁ, Kovács M, Pál E, Komoly S, Houdusse A, Málnási-Csizmadia A.

Cell. 2020 Oct 15;183(2):335-346.e13. doi: 10.1016/j.cell.2020.08.050. Epub 2020 Oct 8.

PMID: 33035452

2. Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential.

Rauscher AÁ, Gyimesi M, Kovács M, Málnási-Csizmadia A.

Trends Biochem Sci. 2018 Sep;43(9):700-713. doi: 10.1016/j.tibs.2018.06.006. Epub 2018 Jul 26.

PMID: 30057142 Review.

3. Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke.

Pénzes M, Túrós D, Máthé D, Szigeti K, Hegedűs N, Rauscher AÁ, Tóth P, Ivic I, Padmanabhan P, Pál G, Dobolyi Á, Gyimesi M, Málnási-Csizmadia A.

Theranostics. 2020 Apr 6;10(12):5341-5356. doi: 10.7150/thno.42077. eCollection 2020.

PMID: 32373216

4. Emerging complex pathways of the actomyosin powerstroke.

Málnási-Csizmadia A, Kovács M.

Trends Biochem Sci. 2010 Dec;35(12):684-90. doi: 10.1016/j.tibs.2010.07.012.

PMID: 20801044

5. Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2.

Gyimesi M, Rauscher AÁ, Suthar SK, Hamow KÁ, Oravecz K, Lőrincz I, Borhegyi Z, Déri MT, Kiss ÁF, Monostory K, Szabó PT, Nag S, Tomasic I, Krans J, Tierney PJ, Kovács M, Kornya L, Málnási-Csizmadia A.

J Pharmacol Exp Ther. 2021 Mar;376(3):358-373. doi: 10.1124/jpet.120.000167. Epub 2021 Jan 19.

PMID: 33468641

6. Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues.

Suthar SK, Rauscher AÁ, Winternitz M, Gyimesi M, Málnási-Csizmadia A.

J Pharm Biomed Anal. 2021 Sep 10;204:114246. doi: 10.1016/j.jpba.2021.114246. Epub 2021 Jul 6.

PMID: 34271288

7. A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative.

Várkuti BH, Képiró M, Horváth IÁ, Végner L, Ráti S, Zsigmond Á, Hegyi G, Lenkei Z, Varga M, Málnási-Csizmadia A.

Sci Rep. 2016 May 31;6:26141. doi: 10.1038/srep26141.

PMID: 27241904

8. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor.

Képiró M, Várkuti BH, Végner L, Vörös G, Hegyi G, Varga M, Málnási-Csizmadia A.

Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8211-5. doi: 10.1002/anie.201403540. Epub 2014 Jun 20.

PMID: 24954740

9. Azidoblebbistatin, a photoreactive myosin inhibitor.

Képiró M, Várkuti BH, Bodor A, Hegyi G, Drahos L, Kovács M, Málnási-Csizmadia A.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9402-7. doi: 10.1073/pnas.1202786109. Epub 2012 May 30.

PMID: 22647605

10. Effect of allosteric inhibition of non-muscle myosin 2 on its intracellular diffusion.

Horváth ÁI, Gyimesi M, Várkuti BH, Képiró M, Szegvári G, Lőrincz I, Hegyi G, Kovács M, Málnási-Csizmadia A.

Sci Rep. 2020 Aug 7;10(1):13341. doi: 10.1038/s41598-020-69853-8.

PMID: 32769996

11. Molecular tattoo: subcellular confinement of drug effects.

Képiró M, Várkuti BH, Rauscher AA, Kellermayer MSZ, Varga M, Málnási-Csizmadia A.

Chem Biol. 2015 Apr 23;22(4):548-558. doi: 10.1016/j.chembiol.2015.03.013. Epub 2015 Apr 16.

PMID: 25892202

Szent-Györgyi legacy

Albert Szent-Györgyi, a Hungarian physiologist, made significant contributions to the understanding of muscle contraction and the role of myosin. His groundbreaking work laid the foundation for further research in the field and inspired generations of Hungarian scientists to follow in his footsteps.

Szent-Györgyi's legacy is marked by his pioneering research of molecular mechanisms of energy production from sugar metabolism, in particular by the isolation and identification of vitamin C, for which he received the Nobel Prize in Physiology or Medicine in 1937.

Later, he and his colleagues identified myosin and actin, revealing the molecular mechanism of muscle contraction. His work not only advanced our understanding of muscle physiology, but also fostered a tradition of excellence in Hungarian scientific research, with subsequent researchers building on his discoveries to further unravel the complexities of muscle contraction, and the role of diverse myosins in essential and multifaceted cellular processes.